Title of article
A new convenient synthesis of N-acyl-2-(dimethoxyphosphoryl)glycinates
Author/Authors
Mazurkiewicz، نويسنده , , Roman and Ku?nik، نويسنده , , Anna، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
3439
To page
3442
Abstract
Easily accessible N-acyl-2-triphenylphosphonioglycinate tetrafluoroborates react smoothly with trimethylphosphite in the presence of methyltriphenylphosphonium iodide to give N-acyl-2-(dimethoxyphosphoryl)glycinates in good or very good yields. The dimethoxyphosphorylglycinates may be isolated by column chromatography, or used directly for the Wadsworth–Emmons synthesis of α,β-dehydro-α-amino acids in a one-pot procedure without purification.
Keywords
Wadsworth–Emmons reaction , Mitsunobu reaction , Michaelis–Arbuzov reaction , ?-Dehydro-?-amino acids , N-Acyl-2-(dimethoxyphosphoryl)glycinates , ?
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850324
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