Title of article
Novel route to 5-position vinyl derivatives of thiolactomycin: olefination versus deformylation
Author/Authors
Kim، نويسنده , , Pilho and Barry III، نويسنده , , Clifton E. and Dowd، نويسنده , , Cynthia S.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
3447
To page
3451
Abstract
Vinyl and diene derivatives of thiolactomycin have been prepared via Horner–Wadsworth–Emmons olefination from protected 5-formyl-3,5-dimethylthiotetronic acid. Several 4-position protecting groups and a variety of phosphonates were evaluated, with MOM protection and β-ketophosphonates yielding the highest ratio of the desired product to deformylated product.
Keywords
Thiolactomycin , Olefination , Deformylation
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850326
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