Author/Authors :
Fiore، نويسنده , , Lucia and Plebani، نويسنده , , Alessandro and Buttinelli، نويسنده , , Gabriele and Fiore، نويسنده , , Stefano and Donati، نويسنده , , Valentina and Marturano، نويسنده , , Jill and Soresina، نويسنده , , Annarosa and Martire، نويسنده , , Baldassarre and Azzari، نويسنده , , Chiara and Nigro، نويسنده , , Giovanni and Cardinale، نويسنده , , Fabio and Trizzino، نويسنده , , Antonino a، نويسنده ,
Abstract :
Patients with agammaglobulinemia may excrete enteroviruses, including vaccine-derived poliovirus, for prolonged periods of time. This poses a risk to the patients but it also may pose a risk to the population after eradication of poliovirus and the cessation of routine vaccination. To assess this risk, a pilot study was performed to identify potential poliovirus long-term excretors in a cohort of 38 patients with a definite/presumptive diagnosis of X-linked agammaglobulinemia (XLA). Stool samples were analyzed to detect any polio or other enteroviruses replicating in the gut and neutralizing antibodies against polioviruses were measured in the sera. No viruses were isolated from the stool samples and most sera had neutralizing antibody levels against all three poliovirus serotypes considered by the WHO to be protective in immunocompetent individuals. This suggests that long-term excretion of enteroviruses in patients with agammaglobulinemia is relatively uncommon.
