Title of article
Alkynylation of halo pyrimidines under Pd/C–copper catalysis: regioselective synthesis of 4- and 5-alkynylpyrimidines
Author/Authors
Pal، نويسنده , , Manojit and Batchu، نويسنده , , Venkateswara Rao and Swamy، نويسنده , , Nalivela Kumara and Padakanti، نويسنده , , Srinivas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
6
From page
3923
To page
3928
Abstract
5-Bromo-4-chloro-6-methylpyrimidines underwent facile Pd/C–Cu catalyzed coupling reactions with a variety of terminal alkynes, which resulted in the corresponding 4-alkynyl-5-bromopyrimidines, regioselectively, with good yields. 4-Chloro-5-iodo-6-methylpyrimidine, however, yielded the corresponding 5-alkynyl-4-chloropyrimidines under the same reaction conditions.
Keywords
5-Bromo-4-chloro-6-methylpyrimidine , 4-Alkynyl-5-bromopyrimidine , palladium catalyst , Terminal alkynes
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850566
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