Solvent free preparation of amidophosphonates from isocyanides

New amidophosphonates are prepared via a two-step Mannich/Ugi one-pot procedure from isocyanides. Aminophosphonates are readily prepared from primary amines, dialkyl phosphites and carbonyl compounds under LiClO4 catalysis without any solvent. After completion, addition of an isocyanide, an aldehyde and acetic acid give access to phosphono Ugi-type adducts in good to moderate yields.