Title of article
Dicationic (BINAP)palladium-catalyzed enantioselective aldol reaction of aldehydes with a silyl enol ether: a simplified practical procedure
Author/Authors
Kiyooka، نويسنده , , Syun-ichi and Hosokawa، نويسنده , , Satomi and Tsukasa، نويسنده , , Sayaka، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
3959
To page
3962
Abstract
The dicationic ((R)-BINAP)palladium-catalyzed enantioselective aldol reaction of benzaldehyde with 1-phenyl-1-trimethylsilylethene has been reinvestigated regarding the reaction conditions in the presence of ((R)-BINAP)palladium chloride and AgSbF6 with 3 إ molecular sieves. The simplified practical procedure with 1 mol % catalyst loading realized the high performance of 98% yield and 76% ee with reliable reproducibility.
Keywords
Palladium-catalyzed aldol reaction , Palladium enolate , Enantioselective aldol reaction
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850587
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