Title of article
Selective reduction of aromatic azides in solution/solid-phase and resin cleavage by employing BF3·OEt2/EtSH. Preparation of DC-81
Author/Authors
Kamal، نويسنده , , Ahmed and Shankaraiah، نويسنده , , N. and Reddy، نويسنده , , K. Laxma and Devaiah، نويسنده , , V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
4253
To page
4257
Abstract
An efficient method for the reduction of aromatic azides in both solution and solid-phase has been developed by employing BF3·OEt2/EtSH. This report also describes resin cleavage employing this reagent system. Further, this protocol has been utilized for the solution as well as the solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepines, including the naturally occurring antibiotic DC-81 and fused [2,1-b]quinazolinones.
Keywords
reductive cyclization , 4]benzodiazepines , solid-phase synthesis , Boron trifluoride diethyletherate , Resin cleavage
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850731
Link To Document