Title of article
Trichiol and 3-epitrichiol acetate, novel cytotoxic sterols with an unprecedented 2,6-dioxabicyclo[2.2.2]octan-3-one ring system from the myxomycete Trichia favoginea var. persimilis
Author/Authors
Kaniwa، نويسنده , , Kouken and Ohtsuki، نويسنده , , Takashi and Sonoda، نويسنده , , Tomomi and Yamamoto، نويسنده , , Yukinori and Hayashi، نويسنده , , Masahiko and Kamiyama، نويسنده , , Kanki and Ishibashi، نويسنده , , Masami، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
4351
To page
4354
Abstract
Trichiol (1) and 3-epitrichiol acetate (2), two new sterols, have been isolated from field-collected fruit bodies of the myxomycete, Trichia favoginea var. persimilis, and their structures elucidated by spectral data. Trichiol (1) and 3-epitrichiol acetate (2) possess an unprecedented 2,6-dioxabicyclo[2.2.2]octan-3-one ring system. Trichiol (1) was cytotoxic against HeLa cells, while compound 2 proved to exhibit reversal effect against TNF-related apoptosis inducing ligand (TRAIL)-resistant Jurkat cell lines.
Keywords
Myxomycete , Trichia favoginea var. persimilis , Fruit body , 2 , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850784
Link To Document