Title of article
A highly efficient microwave-assisted solvent-free synthesis of α- and β-2′-deoxy-1,2,3-triazolyl-nucleosides
Author/Authors
Guezguez، نويسنده , , Raja and Bougrin، نويسنده , , Khalid and El Akri، نويسنده , , Khalid and Benhida، نويسنده , , Rachid، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
4807
To page
4811
Abstract
Microwave activation coupled with Cu(I) catalysis, under solvent-free conditions, was found to dramatically enhance the 1,3-dipolar cycloaddition between azido-2′-deoxyribose and terminal alkynes. The process is highly efficient and quantitatively affords, in few minutes, the corresponding 4-substituted 1,2,3-triazolyl-nucleosides.
Keywords
1 , 3-dipolar cycloaddition , Microwave activation , Cu(I)/SiO2 , Regiocontrolled process , nucleoside analogs
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851202
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