Chromatography-free product separation in the Mitsunobu reaction
Author/Authors :
Proctor، نويسنده , , Anthony J. and Beautement، نويسنده , , Kevin and Clough، نويسنده , , John M. and Knight، نويسنده , , David W. and Li، نويسنده , , Yingfa Li، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Pages :
4
From page :
5151
To page :
5154
Abstract :
Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product.
