A stereoselective synthesis of the C11–C19 fragment of (+)-peloruside A

A new route to the synthesis of the C11–C19 fragment of peloruside A is described, which includes an aldol reaction with ethyl acetoacetate, β-hydroxyl-directed reduction of β-hydroxy ketone, as well as methylation of C13 hydroxyl moiety in the system of MeI–Ag2O–MgSO4–CH2Cl2.