Title of article :
A convenient synthetic route to 2-aryl-N-tosylazetidines and their ZnX2 (X = I, OTf) mediated regioselective nucleophilic ring opening reactions: synthesis of γ-iodoamines and tetrahydropyrimidines
Author/Authors :
Ghorai، نويسنده , , Manas K. and Das، نويسنده , , Kalpataru and Kumar، نويسنده , , Amit and Das، نويسنده , , Animesh، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
A general and convenient synthetic route to various 2-aryl-N-tosylazetidines has been described. Their ZnX2 (X = I, OTf) mediated nucleophilic ring opening with halides and [4+2] cycloaddition reactions with various nitriles have been achieved to afford γ-iodoamines and substituted tetrahydropyrimidines, respectively, in good to excellent yields. A mechanism for the cycloaddition reaction is proposed.
Keywords :
?-Iodoamines , Tetrahydropyrimidine , 2-Aryl-N-tosylazetidine , ZnX2 (X , = , I , OTf)
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
