Title of article :
Enantioselective synthesis of 2-alkyl-2-aryl cyclopentanones by asymmetric epoxidation of tetrasubstituted cyclobutylidene olefins and epoxide rearrangement
Author/Authors :
Shen، نويسنده , , Yumei and Wang، نويسنده , , Bin and Shi، نويسنده , , Yian، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
This letter describes a highly enantioselective epoxidation of tetrasubstituted benzylidenecyclobutanes using glucose-derived ketone as catalyst and oxone as oxidant. The Et2AlCl promoted rearrangement of the resulting epoxides provides 2-alkyl-2-aryl cyclopentanones with high ees.
Keywords :
Asymmetric epoxidation , 2-Alkyl-2-aryl cyclopentanone , Chiral dioxirane , Epoxide rearrangement , Chiral quaternary carbon , Tetrasubstituted olefin
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
