Title of article :
Proline-catalyzed direct asymmetric aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with ketones
Author/Authors :
Funabiki، نويسنده , , Kazumasa and Yamamoto، نويسنده , , Hitoshi and Nagaya، نويسنده , , Hideyuki and Matsui، نويسنده , , Masaki، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
l-Proline-catalyzed direct asymmetric aldol reaction of trifluoroacetaldehyde ethyl hemiacetal with unmodified ketones smoothly occurred at ambient temperature to produce β-hydroxy-β-trifluoromethylated ketones with good to excellent diastereo (up to 96% de) and enantioselectivities (up to 91% ee).
Keywords :
amino acids and derivatives , Fluorine and compounds , Asymmetric reactions , aldol reactions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
