Author/Authors :
Kaasalainen، نويسنده , , Emmi and Tois، نويسنده , , Jan and Russo، نويسنده , , Luca and Rissanen، نويسنده , , Kari and Helaja، نويسنده , , Juho، نويسنده ,
Abstract :
An expedient synthetic route to E-ring extended estrone derivatives is reported. Estrone-derived cyclopentenones were accessed by an intermolecular Pauson–Khand (PK) cycloaddition. It was found that electron donating and withdrawing substituents in the arylalkyne increased and decreased the yields of PK products, respectively. The stereochemistry of the products was elucidated by X-ray and NMR studies.
