Title of article :
Interleukin 4 (IL-4) Blocks the IL-2-Induced Increase in Natural Killer Activity and DNA Synthesis of Decidual CD16−CD56brightNK Cells by Inhibiting Expression of the IL-2 Receptor α, β, and γ
Author/Authors :
Saito، نويسنده , , Shigeru and Umekage، نويسنده , , Hideshi and Nishikawa، نويسنده , , Kiyoshi and Morii، نويسنده , , Takeshi and Narita، نويسنده , , Nobuhiro and Enomoto، نويسنده , , Masahiro and Sakakura، نويسنده , , Shigeyoshi and Harada، نويسنده , , Naoya and Ichijo، نويسنده , , Motohiko and Morikawa، نويسنده , , Hajime، نويسنده ,
Abstract :
The natural killer (NK) activity and DNA synthesis of decidual CD16−CD56brightNK cells were markedly elevated by treatment with interleukin 2 (IL-2). IL-4 did not affect NK activity or DNA synthesis of decidual CD16−CD56brightNK cells, but inhibited the IL-2-induced NK activity and DNA synthesis in a dose-dependent manner. Flow cytometry of decidual mononuclear cells cultured in IL-2 or IL-4 or both IL-2 and IL-4 demonstrated IL-4 inhibition of the expression of the IL-2 receptor α (IL-2Rα), IL-2Rβ, and IL-2Rγ on decidual CD16−CD56brightNK cells. This suggests that IL-4 blocks the IL-2-induced NK activity and DNA synthesis of decidual CD16−CD56brightNK cells by inhibiting the expression of IL-2Rα, IL-2Rβ, and IL-2Rγ.
