Title of article :
Synthesis of 28-19F-amphotericin B methyl ester
Author/Authors :
Tsuchikawa، نويسنده , , Hiroshi and Matsushita، نويسنده , , Naohiro and Matsumori، نويسنده , , Nobuaki and Murata، نويسنده , , Michio and Oishi، نويسنده , , Tohru، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
A fluorinated amphotericin B (AmB) derivative, 28-19F-AmB methyl ester (3), labeled at the polyene moiety, was synthesized by combining chemical synthesis with degradation of a natural product via cross-coupling reactions and macrolactonization. The fluorinated derivative 3 showed antifungal activity similar to that of AmB, and is expected to be a powerful tool for NMR-based investigation of the mechanism of ion-channel formation.
Keywords :
Amphotericin B , fluorine , natural product , Degradation , NMR , chemical synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
