Title of article :
Synthesis of fluorinated cyclic s-trans vinylogous acid and amide ester derivatives
Author/Authors :
Okoro، نويسنده , , Cosmas O. and Fadeyi، نويسنده , , Olugbeminiyi O. and Jackson، نويسنده , , Patrice L. and Richmond، نويسنده , , Rhonda L. and Farmer، نويسنده , , Takeisha، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
A two-step procedure for the preparation of ethyl 4-amino-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (enaminone) and methyl 4-hydroxy-2-oxo-6-(trifluoromethyl)cyclohex-3-ene-1-carboxylate (vinylogous acid) has been accomplished, using reactive Michael acceptors under basic condition. In addition, acyclic trifluoromethylated ester derivatives were isolated as competing by-products. The above compounds represent novel synthetically useful trifluoromethyl building blocks.
Keywords :
Vinylogous , Michael acceptors , Trifluoromethyl , Cyclic enaminone , MOPAC , s-trans
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
