Author/Authors :
Alves، نويسنده , , M. José and Garcيa-Mera، نويسنده , , Xerardo and Vale، نويسنده , , M. Luisa C. and Santos، نويسنده , , Teresa P. and Aguiar، نويسنده , , Fلbio R. and Rodrيguez-Borges، نويسنده , , José E.، نويسنده ,
Abstract :
An efficient preparation of racemic and chiral 2-functionalized-3,5-bis(hydroxymethyl)pyrrolidines is described. The method uses 2-azabicyclo[2.2.1]hept-5-enes, readily obtained from glyoxylates of aliphatic amines and cyclopentadiene, as starting material. The hydroxylation of the double bond followed by the oxidative cleavage of the six-membered ring and in situ reduction of the dialdehyde intermediate gives the title pyrrolidines.
