Title of article
New N-terminal prolyl-dipeptide derivatives as organocatalysts for direct asymmetric aldol reaction
Author/Authors
Zheng، نويسنده , , Jifu and Li، نويسنده , , Yao-Xian and Zhang، نويسنده , , Suo-Qin and Yang، نويسنده , , Song-Tao and Wang، نويسنده , , Xiao-Ming and Wang، نويسنده , , Yong-Zhi and Bai، نويسنده , , Jie and Liu، نويسنده , , Fu-An، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
7793
To page
7796
Abstract
A series of new N-terminal prolyl-dipeptide derivatives have been synthesized and evaluated as organocatalysts for the direct asymmetric aldol reaction of acetone with electron-deficient aromatic aldehydes. At room temperature, the presence of 10 mol % of catalysts 2 and 5 efficiently catalyzes the direct asymmetric aldol reaction to give the aldol adducts with modest to excellent enantiomeric excesses (ee) values, which are up to 96%.
Keywords
organocatalyst , N-terminal prolyl-dipeptide derivatives , direct aldol reaction , Asymmetric catalysis
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1853010
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