Title of article
A simple and effective approach to the synthesis of pyrido[4,3,2-mn]pyrrolo[3,2,1-de]acridine skeleton of arnoamines A and B, pentacyclic marine alkaloids from the ascidian Cystodytes sp.
Author/Authors
Radchenko، نويسنده , , Oleg S. and Balaneva، نويسنده , , Nadezhda N. and Denisenko، نويسنده , , Vladimir A. and Novikov، نويسنده , , Vyacheslav L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
7819
To page
7822
Abstract
Starting from ethyl 5-hydroxy-2-methyl-1-phenylindole-3-carboxylate, a simple and effective approach to the synthesis of pyrido[4,3,2-mn]pyrrolo[3,2,1-de]acridine skeleton of arnoamines A and B, unique pentacyclic alkaloids from the ascidian Cystodytes sp., has been developed. Synthesis of this ring system involves seven steps and produces ethyl 4-methoxy-1-methylpyrido[4,3,2-mn]pyrrolo[3,2,1-de]acridine-2-carboxylate in 41.5% overall yield.
Keywords
1-de]acridines , 3 , Marine alkaloids , Arnoamines A and B , Ascidians , 2 , cytotoxines , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1853023
Link To Document