Title of article :
Transannular anti-Michael addition: formation of 4H-pyrazolo[5,1-c]thiazines
Author/Authors :
Suen، نويسنده , , Yat Fan and Hope، نويسنده , , Hهkon and Nantz، نويسنده , , Michael H. and Haddadin، نويسنده , , Makhluf J. and Kurth، نويسنده , , Mark J.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
The reaction of 2-(diphenylmethylene)thietan-3-one (2) with 1,2,4,5-tetrazines (3a–c) in KOH/MeOH/THF gives 4H-pyrazolo[5,1-c]thiazines (7a–c). This novel condensation reaction proceeds via the intermediacy of an 8-(diphenylmethylene)-2H-1,4,5-thiadiazocin-7(8H)-one (5), which undergoes a multi-step rearrangement including a rare anti-Michael addition.
Keywords :
Anti-Michael addition , 1-c]thiazine , Pyrazole
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
