Author/Authors :
Mitsuda، نويسنده , , Masaru and Tanaka، نويسنده , , Tomoaki and Tanaka، نويسنده , , Toshimitsu and Demizu، نويسنده , , Yosuke and Onomura، نويسنده , , Osamu and Matsumura، نويسنده , , Yoshihiro، نويسنده ,
Abstract :
Kinetic resolution of N-benzoylated vic-amino alcohols was achieved by benzoylation in the presence of copper triflate and (R,R)-Ph-BOX as catalysts. The observed enantioselectivity was moderate to high. The method was applied to a kinetic resolution of racemic prolinol and piperidinemethanol derivatives as well as an asymmetric desymmetrization of 2-amino-1,3-diol derivatives.
Keywords :
Monobenzoylation , Chiral copper complex , vic-Amino alcohol , kinetic resolution
