Author/Authors :
Motoki، نويسنده , , Rie and Tomita، نويسنده , , Daisuke and Kanai، نويسنده , , Motomu and Shibasaki، نويسنده , , Masakatsu، نويسنده ,
Abstract :
Catalytic enantioselective alkenylation and phenylation of trifluoromethyl ketones are described. High enantioselectivity (up to 84% ee) was produced in an alkenylation of aryl trifluoromethyl ketones using a CuF–DTBM-SEGPHOS complex as the catalyst (5–10 mol %) and alkenylsilanes as the nucleophile. This is the first example of catalytic enantioselective alkenylation of trifluoromethyl ketones. The products are versatile chiral building blocks, which contain a trifluoromethyl-substituted tertiary alcohol moiety.
