The first asymmetric total synthesis of (R)-tuberolactone, (S)-jasmine lactone and (R)-δ-decalactone

A general synthetic approach has been developed for the first asymmetric total synthesis of tuberolactone 1, jasmine lactone 2 and δ-decalactone 3. The key step is the selective hydrogenation of triple and endocyclic double bonds in the key intermediate 4.