Author/Authors :
Lin، نويسنده , , Ying-Ju and Wan، نويسنده , , Lei and Sheu، نويسنده , , Jim Jinn-Chyuan and Huang، نويسنده , , Chung-Ming and Lin، نويسنده , , Cheng-Wen and Lan، نويسنده , , Yu-Ching and Lai، نويسنده , , Chih-Ho and Hung، نويسنده , , Chien-Hui and Tsai، نويسنده , , Yuhsin and Tsai، نويسنده , , Chang-Hai and Lin، نويسنده , , Wei-Yong and Liu، نويسنده , , Hsin-Ping and Lin، نويسنده , , Ting-Hsu and Huang، نويسنده , , Yu-M، نويسنده ,
Abstract :
Interleukin-2 (IL-2), one of the crucial immunoregulatory cytokines required for T lymphocyte activation, plays an important role in autoimmune diseases. An IL-2 genetic G/T polymorphism (rs2069763) has been linked with multiple sclerosis and rheumatoid arthritis. We tested a hypothesis that this polymorphism confers systemic lupus erythematosus (SLE) susceptibility. Study participants were Han Chinese SLE patients and a healthy control group in Taiwan. Our results indicate (a) a significantly higher G allele frequency in SLE patients (P = 1.91 × 10− 14; OR = 3.94; 95% CI = 2.74–5.66), (b) a significantly higher G allele frequency in SLE patients with antinuclear antibodies (ANA) (P = 0.033; OR = 4.21; 95% CI = 1.01–17.51) and (c) a significantly lower G allele frequency in SLE patients with discoid rash (P = 0.019; OR = 0.41; 95% CI = 0.19–0.88). Our results suggest that this polymorphism may be involved in the genetic background of Taiwanese SLE.
