Author/Authors :
Chai، نويسنده , , Qiang and Song، نويسنده , , Chun and Sun، نويسنده , , Zhijun and Ma، نويسنده , , Yudao and Ma، نويسنده , , Chanqin and Dai، نويسنده , , Yong and Andrus، نويسنده , , Merritt B.، نويسنده ,
Abstract :
Novel aza-paracyclophane-oxazoline catalysts 4, 5 were produced from Vögtle’s Rp-2-cyano-aza-paraclycophane and amino alcohols reacted with zinc chloride followed by m-chloroperbenzoic acid. 4′-Benzyl and tert-butyl-S and R-oxazoline variants were produced and explored as catalysts for asymmetric allylation of aldehydes using trichloroallylsilane. With Rp,S-4a (R = tert-butyl) (1.5 mol %) aromatic aldehydes reacted with high yields and selectivities, as with benzaldehyde (95%, 93% ee). Rp,S-4b (R = benzyl) was superior with dihydrocinnamaldehyde (77%, 85% ee).
