Author/Authors :
Speckmann، نويسنده , , C. and Enders، نويسنده , , A. and Woellner، نويسنده , , C. and Thiel، نويسنده , , D. and Rensing-Ehl، نويسنده , , A. and Schlesier، نويسنده , , M. and Rohr، نويسنده , , J. and Jakob، نويسنده , , T. and Oswald، نويسنده , , E. and Kopp، نويسنده , , M.V. and Sanal، نويسنده , , O. and Litzman، نويسنده , , J. and Plebani، نويسنده , , A. and Pietrogrande، نويسنده , , Alessandra Licursi M.C. and Franco، نويسنده , , J.L. and Espanol، نويسنده , , T، نويسنده ,
Abstract :
Dominant-negative mutations in STAT-3 have recently been found in the majority of patients with sporadic or autosomal-dominant hyper IgE syndrome (HIES). Since STAT-3 plays a role in B cell development and differentiation, we analyzed memory B cells in 20 patients with HIES, 17 of which had STAT-3 mutations. All but four patients had reduced non-switched and/or class-switched memory B cells. No reduction in these B cell populations was found in 16 atopic dermatitis patients with IgE levels above 1000 KU/L. There was no correlation between the reduction of memory B cells and the ability to produce specific antibodies. Moreover, there was no correlation between the percentage of memory B cells and the infection history. Analysis of memory B cells can be useful in distinguishing patients with suspected HIES from patients with atopic disease, but probably fails to identify patients who are at high risk of infection.
Keywords :
Hyper IgE Syndrome , B cells , STAT-3 , memory cells , atopic dermatitis
