Nafion-H mediated selective deprotection of terminal isopropylidene acetals and trityl ethers. Application in the synthesis of a substituted piperidone

A facile chemoselective hydrolysis of terminal isopropylidene acetals has been achieved in good to excellent yields within 2–4 h using Nafion-H in methanol at ambient temperature. This procedure has been employed to synthesize a substituted piperidone derivative. Similarly, trityl ethers are also deprotected to the corresponding alcohols in excellent yields using Nafion-H at room temperature.