Author/Authors :
Hojo، نويسنده , , Hironobu and Onuma، نويسنده , , Yuko and Akimoto، نويسنده , , Yuri and Nakahara، نويسنده , , Yuko and Nakahara، نويسنده , , Yoshiaki، نويسنده ,
Abstract :
A new method for the preparation of peptide thioester by the post-solid phase peptide synthesis (SPPS) approach was developed. A series of N-alkyl cysteine derivatives were prepared and used as the C-terminus residue of the peptides prepared by the Fmoc SPPS. The synthetic peptides released from resin by TFA were readily converted to the peptide thioester in aqueous 3-mercaptopropionic acid (MPA) without significant side reactions.
