Author/Authors :
Tenorio، نويسنده , , Allan R. and Spritzler، نويسنده , , John and Martinson، نويسنده , , Jeffrey and Gichinga، نويسنده , , Caroline N. and Pollard، نويسنده , , Richard B. and Lederman، نويسنده , , Michael M. and Kalayjian، نويسنده , , Robert C. and Landay، نويسنده , , Alan L.، نويسنده ,
Abstract :
T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV− and younger HIV− subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = − 0.45, p = 0.002) and Candida (r = − 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.
