Application of intramolecular Dِtz reaction to the synthesis of ansa-compounds: concise synthesis of arnebinol

Fischer carbene complexes having long alkynyloxy chains regioselectively produced oxametacyclophanes via the intramolecular Dِtz reaction. The utility of this reaction was demonstrated in the synthesis of arnebinol, an ansa-type terpenoid, from geranyl acetate in six steps.