Author/Authors :
Araujo، نويسنده , , Jacqueline and Segat، نويسنده , , Ludovica and Guimarمes، نويسنده , , Rafael L. and Brandمo، نويسنده , , Lucas A.C. and Souza، نويسنده , , Paulo E.R. and Santos، نويسنده , , Sérgio and Soares، نويسنده , , Thereza S. and Falcمo، نويسنده , , Elcy A. and Rodrigues، نويسنده , , Fernanda and Carvalho Jr، نويسنده , , Ronaldo and de Lima-Filho، نويسنده , , José Luiz and A، نويسنده ,
Abstract :
In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC).
ndings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease.
the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D.
Keywords :
type 1 , Celiac disease , autoimmune , Thyroiditis , Mannose binding lectin , polymorphisms , diabetes mellitus
