Title of article
Diaporthichalasin, a novel CYP3A4 inhibitor from an endophytic Diaporthe sp.
Author/Authors
Pornpakakul، نويسنده , , Surachai and Roengsumran، نويسنده , , Sophon and Deechangvipart، نويسنده , , Suchon and Petsom، نويسنده , , Amorn and Muangsin، نويسنده , , Nongnuch and Ngamrojnavanich، نويسنده , , Nattaya and Sriubolmas، نويسنده , , Nongluksna and Chaichit، نويسنده , , Narongsak and Ohta، نويسنده , , Tomihisa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
651
To page
655
Abstract
A novel CYP3A4 inhibitor, diaporthichalasin, together with pycnidione were isolated from an endophytic fungus, Diaporthe sp. Their structures were elucidated on the basis of spectral data and the structure of diaporthichalasin was confirmed by X-ray crystallographic analysis. Diaporthichalasin exhibited significantly potent inhibition of CYP3A4 with an IC50 value of 0.626 μM, while the IC50 value of pycnidione was 465 μM.
Keywords
endophytic fungi , cytochalasin , Phomopsichalasin , Diaporthe , CYP3A4 inhibitor , Secondary Metabolite
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854028
Link To Document