Title of article
A two-step procedure for the preparation of mono-protected bis-N-heterocyclic alkyl ether systems
Author/Authors
Chao، نويسنده , , Jianhua and Israiel، نويسنده , , Mariam and Zheng، نويسنده , , Junying and Aki، نويسنده , , Cynthia، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
791
To page
794
Abstract
A two-step convenient sequence for the synthesis of previously inaccessible mono-Boc-protected bis-N-heterocyclic alkyl substituted ether derivatives 4 is described. Mitsunobu protocol was applied to the preparation of pyridinyl ether precursor 5. The reduction of the electron rich pyridinyl system 5 has been achieved catalytically using the combination of PtO2–H2SO4 or PtO2–pTsOH under a hydrogen atmosphere maintained by a gas balloon at ambient temperature.
Keywords
Bis-N-heterocyclic alkyl ethers , PtO2–H2SO4 mediated reduction , Mitsunobu reaction
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854072
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