Title of article :
A concise synthetic pathway towards 5-substituted indolizidines
Author/Authors :
Varga، نويسنده , , Tamلs R. and Nemes، نويسنده , , Péter and Mucsi، نويسنده , , Zoltلn and Scheiber، نويسنده , , Pلl، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
The total synthesis of 5-(2′-hydroxyethyl)indolizidine via 5-thioindolizidinone is described. The key step is the transformation of 5-thioindolizidinone via Eschenmoser’s sulfide contraction. The racemic mixture of 5R,9R- and 5S,9S-5-(2′-hydroxyethyl)indolizidine was obtained in seven steps in 17% overall yield from 2-allyl cyclopentanone.
Keywords :
5-Thioindolizidinone , 5-Substituted indolizidines , 2-Allyl cyclopentanone , Eschenmoser’s sulfide contraction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
