Author/Authors :
Engstrom، نويسنده , , Kenneth M. and Henry، نويسنده , , Rodger F. and Marsden، نويسنده , , Ian، نويسنده ,
Abstract :
A linear synthesis of the glucuronide metabolite of ABT-751 was replaced with a convergent synthesis that features direct glycosidic coupling between the aglycone and a trichloroacetimidate glucuronyl donor. Structural elucidation of a unique and unexpected difluoroboron complex of the desired glycosidic coupling product along with optimization of the synthetic steps is described.
