Author/Authors :
Chien، نويسنده , , Shih-Chang and Chang، نويسنده , , Jang-Yang and Kuo، نويسنده , , Ching-Chuan and Hsieh، نويسنده , , Cheng-Chih and Yang، نويسنده , , Ning-Sun and Kuo، نويسنده , , Yueh-Hsiung، نويسنده ,
Abstract :
The novel skeleton compounds, chamaecypanone C (3) and obtunorlignan A (4) were isolated from the heartwood of Chamaecyparis obtusa var. formosana. The structure of 3 was elucidated as a dimeric of monoterpene and norlignan with tricyclo[5.2.2.02.6]undecane and the structure of 4 was elucidated as a norlignan skeleton by spectroscopic methods. Compound 3 exhibits potent cytotoxic activity against several human cancer cells with IC50 values ranging from 0.19 to 0.52 μM, whereas 4 has no activity.
