Author/Authors :
Russell، نويسنده , , Henry F. and Bremner، نويسنده , , John B. and Bushelle-Edghill، نويسنده , , Jennifer and Lewis، نويسنده , , Melissa R. and Thomas، نويسنده , , Stacey R. and Bates II، نويسنده , , Floyd، نويسنده ,
Abstract :
Reaction of primary aromatic amines with peroxidic tetrahydrofuran (THF) in the presence of hydrogen and 10% palladium on carbon catalyst results in THF ring opening to give 4-N-arylamino-1-butanols in a good yield. The reaction mechanism is believed to involve a free-radical sequence resulting in an imino alcohol subsequently reduced to product.
Keywords :
4-Amino-1-butanols , palladium catalyzed , Ring opening , Hydrogenation , Tetrahydrofuran hydroperoxide
