Title of article
The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy
Author/Authors
Ellis، نويسنده , , Gemma L. and O’Neil، نويسنده , , Ian A. and Ramos، نويسنده , , V. Elena and Kalindjian، نويسنده , , S. Barret and Chorlton، نويسنده , , Alan P. and Tapolczay، نويسنده , , David J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
1687
To page
1690
Abstract
Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854374
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