Toward the total synthesis of Scleritodermin A: preparation of the C1–N15 fragment

The synthesis of the C1–N15 fragment of the marine natural product Scleritodermin A has been accomplished through a short and stereocontrolled sequence. Highlights of this route include the synthesis of the novel ACT fragment and the formation of the α-keto amide linkage by the use of a highly activated α,β-ketonitrile.