Title of article
First stereoselective total synthesis of (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one
Author/Authors
Radha Krishna، نويسنده , , Palakodety and Srinivas، نويسنده , , Ravula، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
3
From page
2013
To page
2015
Abstract
A stereoselective total synthesis of (6R)-6-[(4R,6R)-4,6-dihydroxy-10-phenyldec-1-enyl]-5,6-dihydro-2H-pyran-2-one is reported. The strategy utilizes an iterative Jacobsen hydrolytic kinetic resolution, ring opening with a chiral propargylic synthon and a preferential (Z)-Wittig olefination reaction and lactonization as the key steps.
Keywords
?-pyrone , 1 , 3-anti-Polyol , (Z)-Wittig olefination reaction , Lactonization , Jacobsen hydrolytic kinetic resolution
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854489
Link To Document