Design, synthesis and biological evaluation of new oxazines with potential antiparasitic activity

A series of new oxazines with potential antiparasitic activity was prepared using Diels–Alder reactions, based on terpenes derived from eucarvone as dienes and nitrosoarenes with different electronic characteristics as dienophiles. The biological activity was evaluated with in vitro assays against Plasmodium falciparum, Trypanosoma cruzi and Trypanosoma brucei rhodesiense. Some of these oxazines have activities in the 20–50 μM range, and may be leaders for the development of novel antiparasitic drugs with improved pharmacological properties.