Title of article :
A physiological role for inducible FOXP3+ TREG cells: Lessons from women with reproductive failure
Author/Authors :
Gabriel and Arruvito، نويسنده , , Lourdes and Sotelo، نويسنده , , Ana I. and Billordo، نويسنده , , Ariel and Fainboim، نويسنده , , Leonardo، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
10
From page :
432
To page :
441
Abstract :
We have previously shown a decreased frequency and function of Tregs in women suffering from recurrent spontaneous abortions (RSA). In the current study, we first investigated the expression of FOXP3 after T-cell activation. We observed that expression of FOXP3 in activated PBMCs was already present above baseline before any cell division, indicating that it was induced in cells that were previously negative for this transcription factor. Because RSA women showed a more limited expansion of FOXP3-positive cells, we next assessed the role of IL-2 signaling through STAT5, which is known to be required for generation of inducible Tregs (iTregs). We demonstrated not only that TGF-β and IL-2 were diminished but also that the IL-2–STAT-5 signaling axis was down regulated in RSA women. Finally, in addition to a limited FOXP3+ cells expansion in vitro, iTregs from RSA women showed a strikingly lower suppressor activity.
Keywords :
STAT-5 , Human reproduction , Inducible Treg cells , IL-2
Journal title :
Clinical Immunology
Serial Year :
2010
Journal title :
Clinical Immunology
Record number :
1854676
Link To Document :
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