Title of article
Protecting group directed ring-closing metathesis (RCM): the first total synthesis of an anti-malarial nonenolide
Author/Authors
Mohapatra، نويسنده , , Debendra K. and Ramesh، نويسنده , , Dhondi K. and Giardello، نويسنده , , Michael A. and Chorghade، نويسنده , , Mukund S. and Gurjar، نويسنده , , Mukund K. and Grubbs، نويسنده , , Robert H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
2621
To page
2625
Abstract
The first synthesis of a newly found naturally occurring anti-malarial nonenolide is described. A pivotal step in the synthesis is the ring-closing metathesis of a dienoic ester prepared by coupling an acid and alcohol that were stereoselectively synthesized from (S)-α-hydroxy-γ-butyrolactone and 1,2-O-isopropylidene d-glyceraldehyde, respectively.
Keywords
ring-closing metathesis , Nonenolide , Anti-malarial agent , 1 , Yamaguchi esterification , 2-O-Isopropylidene d-glyceraldehyde
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854693
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