Author/Authors :
Villar، نويسنده , , Luisa M. and Espiٌo، نويسنده , , Mercedes and Cavanillas، نويسنده , , Marيa L. and Roldلn، نويسنده , , Ernesto and Urcelay، نويسنده , , Elena and de la Concha، نويسنده , , Emilio G. and Sلdaba، نويسنده , , Maria C. and Arroyo، نويسنده , , Rafael and Gonzلlez-Porqué، نويسنده , , Pedro and ءlvarez-Cermeٌo، نويسنده , , José C.، نويسنده ,
Abstract :
We described previously that multiple sclerosis (MS) patients with oligoclonal IgM against myelin lipids (M+) develop an aggressive disease. Our aim was to assess possible mechanisms regulating the production of these antibodies. We studied B cell subsets in 180 patients with MS, and 69 with other neurological diseases. M+ MS patients showed a moderate increase of CD5+ B-cell percentage in peripheral blood and a considerable augment of these cells in cerebrospinal fluid (CSF) that correlated with intrathecal IgM production. The appearance of CD5+ B cells into the central nervous system (CNS) was related to increased CXCL13 and TNF-alpha levels in CSF. Moreover, the presence of oligoclonal IgM associated with a SNP at position −376 of the TNF-alpha promoter.
results help to elucidate the B lymphocytes responsible for intrathecal IgM secretion in MS and the origin of this abnormal B-cell response in patients with aggressive MS.
