Title of article
An efficient synthesis of (+)-decursinol from umbelliferone
Author/Authors
Lee، نويسنده , , Jung Ho and Bang، نويسنده , , Hyun Bae and Han، نويسنده , , Su Young and Jun، نويسنده , , Jong-Gab Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
2889
To page
2892
Abstract
An efficient, practical and enantioselective total synthesis of (+)-decursinol, which has diverse range of biological properties including anti-cancer, anti-Helicobacter pylori, and strong antinociceptive activities, has been achieved in five steps with 41.4% overall yield from umbelliferone. The improved ring construction from coumarin to linear pyranocoumarin has been obtained through quinonemethide intermediate by using phenylboronic acid with propionic acid.
Keywords
Coumarin , Phenylboronic acid , Quinonemethide , umbelliferone , decursinol
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854772
Link To Document