Author/Authors :
Paolini، نويسنده , , Ilaria and Nuti، نويسنده , , Francesca and de la Cruz Pozo-Carrero، نويسنده , , Maria and Barbetti، نويسنده , , Francesca and Kolesinska، نويسنده , , Beata and Kaminski، نويسنده , , Zbigniew J. and Chelli، نويسنده , , Mario and Papini، نويسنده , , Anna M.، نويسنده ,
Abstract :
Optimization of coupling reactions of glycosylamines with Fmoc-protected aspartic acid, by microwave approach, is described. Different reaction conditions, quantities of substrates and solvents were tested to develop simple and reproducible methodologies. The best results were obtained using new triazine-based coupling reagents with a monomode microwave Discover® BenchMate™ instrument (CEM). The N-glycosyl amino acids were then deprotected to achieve final products for SPPS.
Keywords :
Synthetic glycopeptide probe , Coupling reagent , Solid-phase peptide synthesis , Microwave-assisted synthesis , N-Glycosyl amino acids
