Author/Authors :
Achard، نويسنده , , Thierry J.R. and Belokon’، نويسنده , , Yuri N. and Hunt، نويسنده , , Jamie and North، نويسنده , , Michael and Pizzato، نويسنده , , Francesca، نويسنده ,
Abstract :
N,N-Diphenyl-α-haloacetamides undergo Darzens condensations with aldehydes under heterogeneous reaction conditions in the presence of a metal hydroxide base. By appropriate choice of solvent, base and halide, very high diastereoselectivities favouring formation of the cis- or trans-epoxide can be obtained.
