Author/Authors :
Ohishi، نويسنده , , Takahiro and Nanba، نويسنده , , Hirokazu and Sugawara، نويسنده , , Masanobu and Izumida، نويسنده , , Masashi and Honda، نويسنده , , Tatsuya and Mori، نويسنده , , Kohei and Yanagisawa، نويسنده , , Satohiro and Ueda، نويسنده , , Makoto and Nagashima، نويسنده , , Nobuo and Inoue، نويسنده , , Kenji، نويسنده ,
Abstract :
A scalable and cost-effective synthesis of d- and l-α-methylcysteine is described. A key step is d-selective cyclization of N-carbamoyl S-tert-butyl-d,l-α-methylcysteine catalyzed by hydantoinase. d-5-tert-Butylthiomethyl-5-methylhydantoin and N-carbamoyl S-tert-butyl-l-α-methylcysteine were obtained with excellent yield and optical purity, and these compounds were easily separated by filtration. After hydrolysis and cleavage of the tert-butyl group, d- and l-α-methylcysteine hydrochloride were obtained.
Keywords :
enantioselective synthesis , ?-Methylcysteine , hydantoinase , tert-Butyl group , Scalable process
